By Galen

This ebook deals the 1st serious version of Galen's De locis affectis (On the affected elements) making an allowance for all recognized Greek textual witnesses. It offers an advent, which describes the textual culture, in addition to an entire German translation, an in depth statement at the work's language and content material, and huge indices.

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Extra info for Galeni De locis affectis I–II / Galen. Über das Erkennen erkrankter Körperteile I–II (Edidit, in linguam Germanicam vertit, commentatus est) (Corpus Medicorum Graecorum)

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In addition, MDMA-induced reinstatement of conditioned place preference after extinction and locomotor sensitization development are each abolished by a 5-HT2) receptor antagonist (RS127445) in wild type mice. Accordingly, MDMA-induced dopamine D1 receptor-dependent phosphorylation of extracellular regulated kinase in nucleus accumbens is abolished in mice lacking functional 5-HT2B receptors. These results underpin the importance of 5-HT2B receptors in the reinforcing properties of MDMA and illustrate the importance of dose-dependent effects of MDMA on serotonin–dopamine interactions (Doly et al.

Moreover, platelet derived growth factor receptor (PDGFR) kinase activity is essential for 5-HT2B-triggered MAPK/cyclin D1, but not cyclin E, signaling pathways. The 5-HT2B receptor activation also increases activity of the Src family kinases c-Src, Fyn, and c-Yes. Strikingly, c-Src, but not Fyn or c-Yes, is the crucial molecule between the Gq protein-coupled 5-HT2B receptor and the cell cycle regulators. Inhibition of c-Src activity is sufficient to abolish the serotonin-induced: (1) PDGFR tyrosine kinase phosphorylation and MAPK activation, (2) cyclin D1 and cyclin E expression levels, and (3) thymidine incorporation.

Denis Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada A. Keith Stewart Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ, USA Peter Storz Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL, USA Jennifer L. Stow Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia Lisa Stowers Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA Julia Strebovsky Department of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany Emanuel E.

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